https://ogma.newcastle.edu.au/vital/access/ /manager/Index ${session.getAttribute("locale")} 5 Ensemble machine learning identifies genetic loci associated with future worsening of disability in people with multiple sclerosis https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:52379 Wed 24 Apr 2024 09:45:59 AEST ]]> The association between disability progression, relapses, and treatment in early relapse onset MS: an observational, multi-centre, longitudinal cohort study. https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:54897 Wed 20 Mar 2024 13:32:33 AEDT ]]> Variation within MBP gene predicts disease course in multiple sclerosis https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:34728 interaction = 0.05) and relapse (pinteraction = 0.02). Functional prediction analysis showed this variant is the target of many transcription factors and the binding sites of miR-218 and miR-188-3p. Conclusions: Our results provide novel insights into the role of genetic variation within the MBP gene predicting MS clinical course, both directly and by interaction with known environmental MS risk factors.]]> Wed 04 Sep 2019 10:04:21 AEST ]]> Estimation of annual probabilities of changing disability levels in Australians with relapsing-remitting multiple sclerosis https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:47837 n = 330), annual transition probabilities were obtained between no/mild (Expanded Disability Status Scale (EDSS) levels 0-3.5), moderate (EDSS 4-6.0) and severe (EDSS 6.5-9.5) disability. Results: From no/mild disability, 6.4% (95% confidence interval (CI): 4.7-8.4) and 0.1% (0.0-0.2) progressed to moderate and severe disability annually, respectively. From moderate disability, 6.9% (1.0-11.4) improved (to no/mild state) and 2.6% (1.1-4.5) worsened. From severe disability, 0.0% improved to moderate and no/mild disability. Male sex, age at onset, longer disease duration, not using immunotherapies greater than 3 months and a history of relapse were related to higher probabilities of worsening. Conclusion: We have estimated probabilities of changing disability levels in Australians with RRMS. Probabilities differed between various subgroups, but due to small sample sizes, results should be interpreted with caution. Our findings will be helpful in predicting long-term disease outcomes and in health economic evaluations of MS.]]> Wed 01 Feb 2023 15:34:54 AEDT ]]> The effect of emerging nutraceutical interventions for clinical and biological outcomes in multiple sclerosis: A systematic review https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:39853 Tue 26 Jul 2022 10:28:34 AEST ]]> Common genetic variation within miR-146a predicts disease onset and relapse in multiple sclerosis https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:43091 Tue 13 Sep 2022 12:26:49 AEST ]]> Midsagittal corpus callosum area and conversion to multiple sclerosis after clinically isolated syndrome: a multicentre Australian cohort study https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:34120 Tue 12 Feb 2019 13:13:57 AEDT ]]> Onset symptoms, Tobacco smoking, and progressive-onset phenotype are associated with a delayed onset of multiple sclerosis, and marijuana use with an earlier onset https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:43333 Thu 15 Sep 2022 14:57:26 AEST ]]> Higher latitude is significantly associated with an earlier age of disease onset in multiple sclerosis https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:29942 -23). A reciprocal relationship was seen for ambient ultraviolet radiation (UVR), with a significantly increasing AAO for patients with MS per each quartile increment of ambient UVR (p=1.56×10-17). We found that the AAO of female patients was ~5 months earlier than male patients (p=0.002). AAO of progressive-onset patients with MS were ~9 years later than relapsing-onset patients (p=1.40×10-265). Conclusions: An earlier AAO in higher latitude regions was found in this worldwide European-descent cohort and correlated inversely with variation in latitudinal UVR. These results suggest that environmental factors which act at the population level may significantly influence disease severity characteristics in genetically susceptible populations.]]> Sat 24 Mar 2018 07:31:01 AEDT ]]> Long-term trajectories of employment status, workhours and disability support pension status, after a first episode of CNS demyelination https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:51774 Mon 18 Sep 2023 14:29:20 AEST ]]> A pro-inflammatory diet in people with multiple sclerosis is associated with an increased rate of relapse and increased FLAIR lesion volume on MRI in early multiple sclerosis: A prospective cohort study https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:51575 Mon 11 Sep 2023 14:30:17 AEST ]]>